On 16 May 2024, Mullein locked themself to two barrels in the middle of a road on Poor Mountain in Roanoke County, Virginia, blocking access to the Mountain Valley Pipeline easement.

Mullein said they were driven to block the road by "the interlocking systems of colonization and capitalism," in light of Israel's U.S.-backed assault on Gaza. Appalachians Against Pipelines reported that the blockade went on for seven hours. Mullein was arrested and charged with two misdemeanors, with their bail set at $2,000.

The Mountain Valley Pipeline is a gas pipeline spanning approximately 300 miles (480km) from northwestern West Virginia into southern Virginia in the United States. Environmental advocates have spent a decade fighting the construction of the pipeline, which started in 2018. The pipeline became operational on 14 June 2024.